TRT’s Transformative Impact on Nail Health in Hypogonadal U.S. Men
Reading Time: 2 minutes Introduction In the United States, where approximately 2.1% of men over 45 suffer from symptomatic hypogonadism, testosterone replacement therapy (TRT) has emerged as a cornerstone intervention for restoring physiological androgen levels. This therapy addresses fatigue, diminished libido, and sarcopenia, yet emerging dermatological research highlights its lesser-known effects on appendageal structures, particularly nails. Onychodystrophy—manifesting as brittleness, ridging, or discoloration—poses cosmetic and functional concerns for aging American males, who prioritize physical vitality. This article synthesizes clinical data, pathophysiological mechanisms, and epidemiological insights from U.S.-based cohorts to elucidate TRT's influence on nail health, offering actionable guidance for endocrinologists and dermatologists. Physiological Foundations of...


