Norditropin Efficacy on Muscle Function in Ambulatory ALS Males: Multicenter RCT
Reading Time: < 1 minute Introduction Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disorder, disproportionately affects motor neurons, leading to inexorable muscle atrophy and weakness. In the United States, ALS incidence is estimated at 1.5-2.0 per 100,000 individuals annually, with males comprising approximately 60% of cases, often presenting earlier and with more pronounced bulbar involvement. Sarcopenia in ALS exacerbates functional decline, impairing quality of life and survival. Norditropin (somatropin), a recombinant human growth hormone (rhGH), modulates anabolic pathways, including insulin-like growth factor-1 (IGF-1) signaling, which may counteract cachexia. Preclinical studies in rodent models demonstrate rhGH preserves myofiber integrity via myogenic regulatory factors. This multicenter, double-blind,...


