
Sildenafil’s Efficacy and Safety in American Males with Chronic Conditions: A Review
Reading Time: 2 minutes Introduction Sildenafil, commonly known by its brand name Viagra, has been a revolutionary medication since its introduction in the late 1990s. Initially developed for the treatment of pulmonary hypertension, it was soon discovered to be highly effective in treating erectile dysfunction (ED). This article aims to review the use of sildenafil in American males with chronic conditions, focusing on its efficacy and safety profile. Efficacy of Sildenafil in Chronic Conditions Sildenafil works by inhibiting the phosphodiesterase type 5 (PDE5) enzyme, which leads to increased levels of cyclic guanosine monophosphate (cGMP), facilitating smooth muscle relaxation and increased blood flow to the...