Hormone Therapy May Benefit Some Women’s Hearts

Hormone replacement therapy (HRT) may do more than ease hot flashes and mood swings. A new study suggests that women who start taking hormones during menopause might get some protection against heart disease without seeing increases in other serious risks.

The study, which was published in the journal BMJ, tested a theory called the timing hypothesis. In older women, many years past menopause, hormone replacement therapy using both estrogen and progesterone has been shown to raise risks for heart attacks, strokes, blood clots, dementia, and breast cancer.

What has been less clear is whether hormones might be safer and more beneficial if they are replaced as they naturally start to drop off, around the time of menopause. Though the results of the new study look promising, experts who were not involved in the research caution that it is not a game-changer.

"This trial is not a trial that's going to change how we prescribe hormone replacement therapy. This isn't going to change practice. There are issues about this trial", says Suzanne Steinbaum, MD, director of Women and Heart Disease at Lenox Hill Hospital in New York City.

But she says the new results are intriguing and should open the door to more research. Women who are symptomatic with hot flashes, difficulty sleeping, mood swings, difficulty concentrating, who are recently menopausal, these women actually might benefit from HRT.

Not just for symptom relief, but for preventing heart attacks and deaths, Steinbaum says. The study randomly split 1,006 healthy Danish women into two groups: The first group got HRT; the second group got no treatment. All the women in the study were near menopause and no more than two years away from their last menstrual period.

The study was designed to run for 20 years. But researchers stopped it early -- after ten years -- when results from the large Women's Health Initiative (WHI) study a decade ago found that women taking combined hormone therapy had more heart attacks, strokes, dangerous blood clots in the legs and lungs, and breast cancer than women taking placebo pills.

References

Hormone Replacement Therapy May Boost Women's Hearts

https://www.medscape.com/viewarticle/893886

Hormone Therapy May Benefit Some Women's Hearts

https://www.webmd.com/menopause/news/20121009/hormone-therapy-benefit-womens-hearts#1

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