Aniracetam without choline — a nootropic prescription drug — is a popular cognitive enhancer that many people find useful in becoming more creative, solving problems and allowing both sides of their brain to work together.
Specifically, Aniracetam has been shown to have the ability to:
- Heighten ability to learn and remember
- Sharpen perception
- Introduce a calming effect, and combat stress
- Quicken reflexes
- Improve Mood
- Dramatically increase verbal fluency
Aniracetam was developed in the 1970’s by Hoffman-LaRoche, a company involved in research, development, and manufacture of medicines, diagnostics, and vitamins.
Aniracetam was first introduced as a nootropic in 1979 and was immediately subjected to an enormous amount of both animal and human research.
Aniracetam is a member of the racetam family, which in addition to aniracetam consists of piracetam, oxiracetam, pramiracetam, and noopept.
When combined with any of these racetams, or for that matter, any other cognitive enhancer, remember that the effects of aniracetam are synergistic (the combined whole is more than the sum of the parts).
The benefits are increased by combining them but in lesser doses.
How Aniracetam Works
Similar to the other racetams, aniracetam’s particular manner of activity is somewhat uncertain. What is known is that aniracetam stimulates the brain’s AMPA receptors, which are the most common CNS glutamate receptors.
These receptors are considered to play a significant role in new learning and retaining memories.
This is important because the brain consists of millions of interneuron networks composed of cells made up of different chemicals.
These neurons communicate with each other by using dendrites (who receive information from other cells) and axon (which transmits information). This information travels through the synapse (connection between neurons) where the dendrites and axon come together.
These receptors are found in the neuron, which allows them to function. One of these neurons is the AMPA receptors, which aniracetam effects by decreasing the receptor sensitivity.
This leads to increased stimulation and focus.
As with the other racetams, Aniracetam increases blood flow to the brain and speeds up its electrical activity.
This increased blood flow has been shown to be helpful in battling degenerative brain diseases like Alzheimer’s and dementia, as well as improving brain performance.
Aniracetam has anxiety-reducing ability without excessive sedation, which makes it safe for many anxiety conditions.
Aniracetam does not decrease choline uptake into the hippocampal cells and encourages acetylcholine release.
Also, Aniracetam increases the release of dopamine and serotonin by way of cholinergic mechanisms in the prefrontal cortex, which seems to improve judgment. This may explain its antidepressant effects.
To make all of this simple, just remember this: Aniracetam has been shown to improve mood by ratcheting up the happy chemicals in the brain: dopamine and serotonin.
These chemicals are also responsible for aniracetam’s calming effect, as well as its ability to increase mental clarity.
Like most other nootropics, aniracetam affects people in many different ways. Some need a significant amount to feel aniracetam’s full effects, while others can take a fraction of the recommended dose and get all the advantages.
The commonly recommended dose is 750-1500 mg, with the first dose taken in the morning and the second dose taken in the afternoon. But even smaller dosages like 100mg may give benefits.
Another thing to consider is this: For some, aniracetam’s effects may not be felt for weeks.
When aniracetam does go to work, the effects are usually fast-acting and short-lived, so this is the reason to take at least two different doses during the day.
In rats, peak levels of aniracetam are reached in a mere 20-30 minutes after oral administration.
In humans, the highest blood levels of aniracetam are reached approximately two hours after administration.
Since aniracetam is fat-soluble, try to take it with foods that are high in healthy fats, which will bump up the absorption rate to nearly 100%.
Still another consideration is the fact that the dosage-response curve of aniracetam is bell-shaped. In other words, there is an optimum dosage, and too much is as ineffectual as too little.
The bottom line? Due to the wide variety of responses, you are advised to experiment, experiment and then experiment some more. Start slowly, notice how aniracetam affects you, and go from there.
Like other nootropics and smart drugs, aniracetam is safe. However, it may be slightly more toxic than piracetam. No drug interactions have been discovered, and there are no reported cases of overdose.
However, there have been a few side effects noted. Here are the most common aniracetam side effects:
Keep in mind that the overwhelming majority of people who take aniracetam report zero side effects.
As always, people can and do respond differently, so if any of these symptoms appear, discontinue use, or lower the dosage. A good plan for some is to take aniracetam every other day, or at least take one or two days off during the week.
Also, most people need to take choline along with aniracetam to prevent headaches.
Why? Because aniracetam (and the other racetam’s) make the brain devour choline. Without sufficient choline, headaches may result. It’s no different than a bodybuilder’s need for more protein.
Choline comes in different forms: Alpha-GPC, choline bitartrate, DMAE, phosphatidylcholine, and CDP-choline.
They all have been proven to work.
Try different kinds, and see what works best for you.
To sum it up, aniracetam is safe, well-researched, relatively cheap and is believed to be anywhere between five to ten times stronger than piracetam.
If you have tried other smart pills and didn’t feel much, consider giving aniracetam a try.
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